Neuroendocrinological approach for examining the mechanisms of action of Toki‐Shakuyaku‐San (TJ‐23) on the activity of tyrosine hydroxylase in the brain

Kazuo Toriizuka, Nobuyoshi Hagino, Katsutoshi Terasawa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Administration of the Kampo medicine, TJ‐23, to ovariectomized rats resulted in decreased tyrosis hydroxylase (TH) activity in the dorsal hippocampus but an increased activity in the ventral tegmental area. A decrease of TH activity in the hypothalamus was not statistically significant. The effect of TJ‐23 was compared to oestrogen in a similar group of rats and it was concluded that the standard drug and TJ‐23 induced similar effects.

Original languageEnglish (US)
Pages (from-to)S70-S72
JournalPhytotherapy Research
Volume7
Issue number7
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • brain tyrosine hydroxylase
  • Kampo medicines
  • rats

ASJC Scopus subject areas

  • Pharmacology

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