Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects

P. L. Delgado, D. S. Charney, L. H. Price, H. Landis, G. R. Heninger

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

The neuroendocrine and behavioral effects of gradual dietary tryptophan (TRP) depletion, utilizing two magnitudes of a 10-day TRP-restriction diet (700 mg/day and 200 mg/day), were studied in 22 healthy subjects. The prolactin response to a 7 gm L-TRP infusion was measured prior to and on day 10 of the diet. Both diets significantly reduced fasting total plasma TRP by 15 to 20%, but only the 200 mg/day TRP diet led to an enhancement of the prolactin response to intravenous L-TRP. Female subjects demonstrated a more robust increase in plasma prolactin following L-TRP infusion pre-diet and exhibited a larger decrease in plasma TRP following dietary TRP restriction compared to males. There were no significant behavioral effects of either diet. Gradual dietary TRP depletion leads to an enhancement of the prolactin response to L-TRP infusion, suggestive of postsynaptic serotonin receptor supersensitivity.

Original languageEnglish (US)
Pages (from-to)2323-2332
Number of pages10
JournalLife Sciences
Volume45
Issue number24
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects'. Together they form a unique fingerprint.

Cite this