Neuroeconomics and adolescent substance abuse: Individual differences in neural networks and delay discounting

Catherine Stanger, Amanda Elton, Stacy R. Ryan, G. Andrew James, Alan J. Budney, Clinton D. Kilts

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: Many adolescents with substance use problems show poor response to evidence-based treatments. Treatment outcome has been associated with individual differences in impulsive decision making as reflected by delay discounting (DD) rates (preference for immediate rewards). Adolescents with higher rates of DD were expected to show greater neural activation in brain regions mediating impulsive/habitual behavioral choices and less activation in regions mediating reflective/executive behavioral choices. Method: Thirty adolescents being treated for substance abuse completed a DD task optimized to balance choices of immediate versus delayed rewards, and a control condition accounted for activation during magnitude valuation. A group independent component analysis on functional magnetic resonance imaging time courses identified neural networks engaged during DD. Network activity was correlated with individual differences in discounting rate. Results: Higher discounting rates were associated with diminished engagement of an executive attention control network involving the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, inferior parietal cortex, cingulate cortex, and precuneus. Higher discounting rates also were associated with less deactivation in a "bottom-up" reward valuation network involving the amygdala, hippocampus, insula, and ventromedial prefrontal cortex. These 2 networks were significantly negatively correlated. Conclusions: Results support relations between competing executive and reward valuation neural networks and temporal decision making, an important, potentially modifiable risk factor relevant for the prevention and treatment of adolescent substance abuse. Clinical trial registration information - The Neuroeconomics of Behavioral Therapies for Adolescent Substance Abuse, http://clinicaltrials.gov/, NCT01093898.

Original languageEnglish (US)
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume52
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Individuality
Substance-Related Disorders
Reward
Prefrontal Cortex
Parietal Lobe
Decision Making
Gyrus Cinguli
Executive Function
Amygdala
Hippocampus
Therapeutics
Magnetic Resonance Imaging
Delay Discounting
Clinical Trials
Brain

Keywords

  • adolescent substance abuse
  • delay discounting
  • functional magnetic resonance imaging
  • neuroeconomics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Neuroeconomics and adolescent substance abuse : Individual differences in neural networks and delay discounting. / Stanger, Catherine; Elton, Amanda; Ryan, Stacy R.; James, G. Andrew; Budney, Alan J.; Kilts, Clinton D.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 52, No. 7, 07.2013.

Research output: Contribution to journalArticle

Stanger, Catherine ; Elton, Amanda ; Ryan, Stacy R. ; James, G. Andrew ; Budney, Alan J. ; Kilts, Clinton D. / Neuroeconomics and adolescent substance abuse : Individual differences in neural networks and delay discounting. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2013 ; Vol. 52, No. 7.
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