Neurocognitive Dysfunction in Survivors of Childhood Brain Tumors

Nicole J. Ullrich, Leanne Embry

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Newer treatments have resulted in increasing numbers of survivors of childhood cancer, for whom neurological and neurocognitive toxicity directly impacts overall functioning and quality of life. There are multiple disease- and host-related factors that influence the development of cancer-related neurocognitive dysfunction, which can progress over time and lead to significant functional impairments. This article provides an overview of the types of neurocognitive deficits seen in survivors of childhood brain tumors, the tools used to assess neurocognitive function, and the factors that impact its severity. This provides a framework for consideration of potential areas for primary prevention by reducing treatment-related toxicity as well as interventions, using behavioral and pharmacologic treatments.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalSeminars in Pediatric Neurology
Volume19
Issue number1
DOIs
StatePublished - Mar 1 2012

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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