Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the 'right stuff'?

Michael Foster Green, Robert S. Kern, David L. Braff, Jim Mintz

Research output: Contribution to journalReview article

2149 Scopus citations

Abstract

There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.

Original languageEnglish (US)
Pages (from-to)119-136
Number of pages18
JournalSchizophrenia bulletin
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

    Fingerprint

Keywords

  • Functional outcome
  • Learning potential
  • Neurocognition
  • Schizophrenia
  • Social cognition

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this