Neurobiologia da síndrome de Tourette: A hipótese auto-imune pós-estreptocócica

Translated title of the contribution: Neurobiology of Tourette's syndrome: The autoimmune post-streptococcal hypothesis

Fernando Machado Vilhena Dias, Arthur Kummer, Anna Gabriela Hounie, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Tourette's syndrome (TS) is characterized by the presence of motor tics and at least one phonic tic. Some clinical similarities with Sydenham's chorea (SC) lead to the hypothesis of a new group of disorders associated with an autoimmune process due to a streptococcal infection (PANDAS). Objective: To review the literature in search of evidence on the existence of post-streptococcal autoimmune mechanisms involved with the etiopathogenesis of TS. Methods: A systematic review with the terms "Tourette", "tic", "PANDAS", "antibodies", "streptococcal" and "rheumatic" was carried on using the MedLine. Results: The search found 238 articles. Fifty and three articles were selected which also had their references reviewed. The results of studies that investigated autoimmune aspects of TS, including anti-streptococcal and anti-basal ganglia anti-bodies, and immune-based therapy, were presented and discussed. Discussion: The evidences to date are not satisfactory regarding a post-streptococcal auto-immune process in ST. The improvement on investigative methods and sample selection might contribute to this question.

Translated title of the contributionNeurobiology of Tourette's syndrome: The autoimmune post-streptococcal hypothesis
Original languagePortuguese
Pages (from-to)228-235
Number of pages8
JournalRevista de Psiquiatria Clinica
Issue number6
StatePublished - 2008
Externally publishedYes


  • Autoimmune
  • Rheumatic fever
  • Streptococcal infection
  • Sydenham's chorea
  • Tics
  • Tourette's syndrome

ASJC Scopus subject areas

  • Psychiatry and Mental health


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