Neuroanatomical correlates of anticipatory anxiety

Eric M. Reiman, Maureen J. Fusselman, Peter T. Fox, Marcus E. Raichle

Research output: Contribution to journalArticlepeer-review

236 Scopus citations


Positron emission tomographic measurements of regional blood flow, a marker of local neuronal activity, were used to investigate the neuroanatomical correlates of a normal emotion. Healthy volunteers were studied before, during, and after anticipation of a painful electric shock. During anticipatory anxiety, there were significant blood flow increases in bilateral temporal poles, the same regions recently implicated in a lactate-induced anxiety attack in patients with panic disorder. Thus, the temporal poles seem to be involved in normal and pathological forms of human anxiety.

Original languageEnglish (US)
Pages (from-to)1071-1074
Number of pages4
Issue number4894
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • General


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