Neuroanatomic changes and their association with cognitive decline in mild cognitive impairment: A meta-analysis

Thomas Nickl-Jockschat, Alexandra Kleiman, Jörg B. Schulz, Frank Schneider, Angela R. Laird, Peter T. Fox, Simon B. Eickhoff, Kathrin Reetz

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Mild cognitive impairment (MCI) is an acquired syndrome characterised by cognitive decline not affecting activities of daily living. Using a quantitative meta-analytic approach, we aimed to identify consistent neuroanatomic correlates of MCI and how they are related to cognitive dysfunction. The meta-analysis enrols 22 studies, involving 917 MCI (848 amnestic MCI) patients and 809 healthy controls. Only studies investigating local changes in grey matter and reporting whole-brain results in stereotactic coordinates were included and analysed using the activation likelihood estimation approach. Probabilistic cytoarchitectonic maps were used to compare the localization of the obtained significant effects to histological areas. A correlation between the probability of grey matter changes and cognitive performance of MCI patients was performed. In MCI patients, the meta-analysis revealed three significant clusters of convergent grey matter atrophy, which were mainly situated in the bilateral amygdala and hippocampus, extending to the left medial temporal pole and thalamus, as well as in the bilateral precuneus. A sub-analysis in only amnestic MCI revealed a similar pattern. A voxel-wise analysis revealed a correlation between grey matter reduction and cognitive decline in the right hippocampus and amygdala as well as in the left thalamus. This study provides convergent evidence of a distinct neuroanatomical pattern in MCI. The correlation analysis with cognitive-mnestic decline further highlights the impact of limbic structures and the linkage with data from a functional neuroimaging database provides additional insight into underlying functions. Although different pathologies are underlying MCI, the observed neuroanatomical pattern of structural changes may reflect the common clinical denominator of cognitive impairment.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalBrain Structure and Function
Issue number1
StatePublished - Jan 2012


  • Activation likelihood estimation approach
  • Cognitive impairment
  • Meta-analysis
  • Mild cognitive impairment
  • Mini-mental state examination
  • Voxel-based morphometry

ASJC Scopus subject areas

  • General Neuroscience
  • Anatomy
  • Histology


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