Neural phenotypes of common and rare genetic variants

Carrie E. Bearden, David C. Glahn, Agatha D. Lee, Ming Chang Chiang, Theo G.M. van Erp, Tyrone D. Cannon, Allan L. Reiss, Arthur W. Toga, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Neuroimaging methods offer a powerful way to bridge the gaps between genes, neurobiology and behavior. Such investigations may be further empowered by complementary strategies involving chromosomal abnormalities associated with particular neurobehavioral phenotypes, which can help to localize causative genes and better understand the genetics of complex traits in the general population. Here we review the evidence from studies using these convergent approaches to investigate genetic influences on brain structure: (1) studies of common genetic variations associated with particular neuroanatomic phenotypes, and (2) studies of possible 'genetic subtypes' of neuropsychiatric disorders with very high penetrance, with a focus on neuroimaging studies using novel computational brain mapping algorithms. Finally, we discuss the contribution of behavioral neurogenetics research to our understanding of the genetic basis of neuropsychiatric disorders in the broader population.

Original languageEnglish (US)
Pages (from-to)43-57
Number of pages15
JournalBiological Psychology
Volume79
Issue number1
DOIs
StatePublished - Sep 2008

Keywords

  • Brain
  • COMT
  • Chromosome 22q11.2
  • Fragile X
  • Genetic
  • Neurofibromatosis I
  • Neuroimaging
  • Psychosis
  • Velocardiofacial syndrome
  • Williams syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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