@article{4575f7b8b0424f81b908e6786bbb151e,
title = "Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study",
abstract = "Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist-edge-palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty-six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre- and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable.",
keywords = "audiovisual integration, fMRI, fist-edge-palm, healthy twin, heritability",
author = "Zhi Li and Jia Huang and Ting Xu and Ya Wang and Ke Li and Zeng, {Ya Wei} and Lui, {Simon S.Y.} and Cheung, {Eric F.C.} and Zhen Jin and Paola Dazzan and Glahn, {David C.} and Chan, {Raymond C.K.}",
note = "Funding Information: Beijing Municipal Science & Technology Commission Grant, Grant/Award Number: Z161100000216138; National Key Research and Development Programme, Grant/Award Number: 2016YFC0906402; Beijing Training Project for the Leading Talents in S & T, Grant/Award Number: Z151100000315020; “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences, Grant/Award Number: XDB02030002; Outstanding Young Investigator Award of the National Science Fund China, Grant/Award Number: 81088001; CAS Key Laboratory of Mental Health, Institute of Psychology Funding Information: This study was supported by grants from the Beijing Municipal Science & Technology Commission Grant (Z161100000216138), the National Key Research and Development Programme (2016YFC0906402), the Beijing Training Project for the Leading Talents in S & T (Z151100000315020), the “Strategic Priority Research Program (B)” of the Chinese Academy of Sciences (XDB02030002), the Outstanding Young Investigator Award of the National Science Fund China (81088001), and a grant from the CAS Key Laboratory of Mental Health, Institute of Psychology. The funding agents had no role in the study design, collection, analysis or interpretation of findings, and the decision to publish the findings.",
year = "2018",
month = mar,
doi = "10.1002/hbm.23935",
language = "English (US)",
volume = "39",
pages = "1438--1448",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "3",
}