Neural correlates of response inhibition for behavioral regulation in humans assessed by functional magnetic resonance imaging

Tatia M.C. Lee, Ho Ling Liu, Ching Mei Feng, Jinwen Hou, Srikanth Mahankali, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

To identify the specific frontal and cingulate regions involved in response inhibition, five Chinese right-handed male volunteers with an attention span reaching or exceeding a 7-digit level participated in this blocked design functional magnetic resonance imaging study. Each block represented one of the two experimental conditions, the Correct Matching or the Incorrect Matching condition. In the Correct Matching condition, the subjects were required to make correct judgement of whether the two 3-digit numbers presented in succession were the same or not; whereas in the Incorrect Matching condition, the participants were instructed to inhibit the correct responses. Bilateral activations of the prefrontal and anterior cingulate as well as the left posterior cingulated cortex were observed while the subjects were exercising response inhibition. The roles of these activations in response inhibition were discussed.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalNeuroscience Letters
Volume309
Issue number2
DOIs
StatePublished - Aug 24 2001

Keywords

  • Cingulate
  • Disinhibition
  • Dorsolateral-prefrontal
  • Inhibition
  • Orbitofrontal
  • Prefrontal

ASJC Scopus subject areas

  • Neuroscience(all)

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