Neural correlates of aggression in medication-naive children with ADHD: Multivariate analysis of morphometry and tractography

Jiook Cha, Tomer Fekete, Francesco Siciliano, Dominik Biezonski, Laurence Greenhill, Steven R Pliszka, Joseph Blader, Amy Krain Roy, Ellen Leibenluft, Jonathan Posner

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aggression is widely observed in children with attention deficit/hyperactivity disorder (ADHD) and has been frequently linked to frustration or the unsatisfied anticipation of reward. Although animal studies and human functional neuroimaging implicate altered reward processing in aggressive behaviors, no previous studies have documented the relationship between fronto-accumbal circuitry - a critical cortical pathway to subcortical limbic regions - and aggression in medication-naive children with ADHD. To address this, we collected behavioral measures and parental reports of aggression and impulsivity, as well as structural and diffusion MRI, from 30 children with ADHD and 31 healthy controls (HC) (mean age, 10±2.1 SD). Using grey matter morphometry and probabilistic tractography combined with multivariate statistical modeling (partial least squares regression and support vector regression), we identified anomalies within the fronto-accumbal circuit in childhood ADHD, which were associated with increased aggression. More specifically, children with ADHD showed reduced right accumbal volumes and frontal-accumbal white matter connectivity compared with HC. The magnitude of the accumbal volume reductions within the ADHD group was significantly correlated with increased aggression, an effect mediated by the relationship between the accumbal volume and impulsivity. Furthermore, aggression, but not impulsivity, was significantly explained by multivariate measures of fronto-accumbal white matter connectivity and cortical thickness within the orbitofrontal cortex. Our multi-modal imaging, combined with multivariate statistical modeling, indicates that the fronto-accumbal circuit is an important substrate of aggression in children with ADHD. These findings suggest that strategies aimed at probing the fronto-accumbal circuit may be beneficial for the treatment of aggressive behaviors in childhood ADHD.

Original languageEnglish (US)
Pages (from-to)1717-1725
Number of pages9
JournalNeuropsychopharmacology
Volume40
Issue number7
DOIs
StatePublished - Feb 4 2015

Fingerprint

Attention Deficit Disorder with Hyperactivity
Aggression
Multivariate Analysis
Impulsive Behavior
Reward
Functional Neuroimaging
Diffusion Magnetic Resonance Imaging
Critical Pathways
Frustration
Prefrontal Cortex
Least-Squares Analysis

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Neural correlates of aggression in medication-naive children with ADHD : Multivariate analysis of morphometry and tractography. / Cha, Jiook; Fekete, Tomer; Siciliano, Francesco; Biezonski, Dominik; Greenhill, Laurence; Pliszka, Steven R; Blader, Joseph; Krain Roy, Amy; Leibenluft, Ellen; Posner, Jonathan.

In: Neuropsychopharmacology, Vol. 40, No. 7, 04.02.2015, p. 1717-1725.

Research output: Contribution to journalArticle

Cha, J, Fekete, T, Siciliano, F, Biezonski, D, Greenhill, L, Pliszka, SR, Blader, J, Krain Roy, A, Leibenluft, E & Posner, J 2015, 'Neural correlates of aggression in medication-naive children with ADHD: Multivariate analysis of morphometry and tractography', Neuropsychopharmacology, vol. 40, no. 7, pp. 1717-1725. https://doi.org/10.1038/npp.2015.18
Cha, Jiook ; Fekete, Tomer ; Siciliano, Francesco ; Biezonski, Dominik ; Greenhill, Laurence ; Pliszka, Steven R ; Blader, Joseph ; Krain Roy, Amy ; Leibenluft, Ellen ; Posner, Jonathan. / Neural correlates of aggression in medication-naive children with ADHD : Multivariate analysis of morphometry and tractography. In: Neuropsychopharmacology. 2015 ; Vol. 40, No. 7. pp. 1717-1725.
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