Nephrotoxicity of nonsteroidal anti-inflammatory drugs

J. Baisac, W. L. Henrich

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are important therapeutic agents in the management of rheumatologic disorders and other pain syndromes. Over the counter availability of the drugs has expanded the usage of the drugs. This article reviews the nephrotoxicity of these drugs, with some emphasis on NSAID-related proteinuria. Although reversibility of renal involvement upon drug discontinuance is the rule, progression to end-stage renal disease has occurred. A proposed guideline for monitoring renal impairment in low- and high-risk patients is also presented.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalMineral and Electrolyte Metabolism
Volume20
Issue number4
StatePublished - Jan 1 1994

Keywords

  • NSAIDs
  • Nephrotoxicity
  • Prostaglandins
  • Proteinuria
  • Renal failure

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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