Nephrotoxicity of contrast media assessed by occlusion arteriography

G. Lund, J. Rysavy, E. Salomonowitz, A. Cragg, Z. Vlodaver, W. Bendell, W. Castaneda-Zuniga, K. Amplatz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The authors describe an experimental model for the study of nephrotoxicity induced by contrast media, based on a standardized injection combined with occlusion of the renal artery so as to expose the kidney to a high concentration of contrast medium for ten minutes. Iopamidol, ioxaglate, and both isosmolar and hyperosmolar saline were well tolerated, but diatrizoate caused marked radiological and pathological changes. This model may be helpful in studies of the mechanisms underlying contrast medium nephrotoxicity and evaluating differences in toxicity between contrast agents.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
Issue number3
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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