Neonatal oligodendrocytes contain and secrete neuregulins in vitro

Timothy D. Raabe, Diana R. Clive, Duanzhi Wen, George H. DeVries

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The factors that influence the development of oligodendrocyte (OLG) progenitors into mature OLGs remain elusive. Recent evidence has suggested that neu differentiation factor (NDF), which is a member of the neuregulin faro y of growth factors, influences the development of glial cells, including Schwann cells, astrocytes, and OLGs. Neurons are postulated to be the source of neuregulins, because neurons closely interact with these glial cells during development. In this report, we have identified the mRNA for both isoform families of NDF in cultured neonatal (immature) OLGs. We have also demonstrated that cultured neonatal OLGs contain and secrete NDF protein. These data raise the possibility that NDF could be used in an autocrine/paracrine loop by neonatal OLGs during development for survival proliferation and/or differentiation.

Original languageEnglish (US)
Pages (from-to)1859-1863
Number of pages5
JournalJournal of neurochemistry
Volume69
Issue number5
DOIs
StatePublished - Nov 1997
Externally publishedYes

Keywords

  • Autocrine
  • Neu differentiation factor
  • Neuregulin
  • Oligodendrocyte

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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