Neoadjuvant hormonal therapy and radical prostatectomy for clinical stage C carcinoma of the prostate

P. NARAYAN, B. A. LOWE, P. R. CARROLL, I. M. THOMPSON

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Objective To determine whether hormonal therapy prior to radical prostatectomy (neoadjuvant hormonal therapy) leads to improved results in patients with stage C prostate cancer. Patients and methods Thirty patients received neoadjuvant hormonal therapy for stage C carcinoma of the prostate. Eighteen patients who responded to treatment subsequently underwent extirpative surgery. Results Fourteen of the 30 patients (47%) were diagnosed as being downstaged to clinical stage B disease following therapy. No major complications occurred. Pathology staging revealed only three patients (10%) to have organ‐confined disease after radical prostatectomy. Conclusions Neoadjuvant hormonal therapy prior to radical prostatectomy offers little probability of rendering patients with clinical stage C carcinoma of the prostate free of disease. Further investigation of the efficacy of this treatment should be accomplished in randomized trials.

Original languageEnglish (US)
Pages (from-to)544-548
Number of pages5
JournalBritish Journal of Urology
Volume73
Issue number5
DOIs
StatePublished - May 1994

Keywords

  • Prostate cancer
  • downstaging
  • hormonal therapy
  • regionally‐advanced

ASJC Scopus subject areas

  • Urology

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