Neither prolactin nor growth hormone restore the nocturnal rise in pineal N-acetyltransferase activity or melatonin content in hypophysectomized rats

I. Sabry, R. J. Reiter

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Hypophysectomy in adult male rats greatly attenuated the nocturnal rise in both pineal N-acetyltransferase (NAT) activity and melatonin content. High nighttime levels of NAT and melatonin were not restored by treating the animals with either prolactin or growth hormone, alone or in combination. Treating intact rats with bromocriptine, which depresses circulating prolactin levels, also was without effect on pineal melatonin synthesis. It appears that neither prolactin nor growth hormone are of major importance in determining pineal melatonin production.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalExperientia
Volume44
Issue number6
DOIs
StatePublished - Jun 1 1988

Keywords

  • N-acetyltransferase
  • Pineal gland
  • growth hormone
  • hypophysectomy
  • melatonin
  • prolactin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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