Nature and the time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats

Russel J. Reiter, David E. Blask, Judy A. Talbot, Marguerite P. Barnett

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

About 80% of male rats that are parathyroidectomized at 23 days of age and are pinealectomized a week later exhibit intermittent seizures and frequently death. Characteristically, the seizures are violent and death is probably a result of asphyxiation. The peak incidence of seizures in these rats occurs within 8 hr after pinealectomy and approximately 50% of the animals die within 48 hr of the operation. Chlordiazepoxide (18-20 mg/kg), diazepam (18-20 mg/kg) or chlorpromazine (20 mg/kg), given as single subcutaneous doses at the time of pinealectomy, delayed the onset of the seizures. Haloperidol (20 mg/kg) had a modest suppressive effect on the seizure activity. Diphenylhydantoin (20 mg/kg) did not affect the percentage of rats that convulsed, the onset of the seizures, the frequency of the seizures, or the 48 hr mortality.

Original languageEnglish (US)
Pages (from-to)386-397
Number of pages12
JournalExperimental Neurology
Volume38
Issue number3
DOIs
StatePublished - Mar 1973
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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