Natural products identification for the treatment of chronic inflammation

S. Bhaskaran, K. V. Dileep, C. Sadasivan, J. Padikkala, H. B. Nair

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Flavonoids embody the most imperative single cluster of phenolics in food; more than 4,000 different types have been recognized. Gossypin, a flavonoid compound originally isolated from the flowers of Hibiscus vitifolius, has been shown to be effective for cleansing kidneys and having antinociceptive effects in traditional/alternative medicine. A wide range of phenolic substances resulting from edible plants have been reported to have noticeable antioxidant and anti-inflammatory actions, which enhance their chemopreventive potential. In this chapter we address the acute and chronic anti-inflammatory properties of gossypin in different in vivo models with inflammation induced by aspirin, carrageenan, formalin, dextran and croton oil. We will also discuss gossypin's antimelanoma properties based on a novel mechanism of action involving the RAF-MEK-ERK pathway. Finally, we will address the possibilities of using gossypin and its rationally designed analogues to develop proprietary drug candidates based on molecular docking studies.

Original languageEnglish (US)
Title of host publicationChronic Inflammation
Subtitle of host publicationCauses, Treatment Options and Role in Disease
PublisherNova Science Publishers, Inc.
Pages217-230
Number of pages14
ISBN (Print)9781628080940
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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