Abstract
Flavonoids embody the most imperative single cluster of phenolics in food; more than 4,000 different types have been recognized. Gossypin, a flavonoid compound originally isolated from the flowers of Hibiscus vitifolius, has been shown to be effective for cleansing kidneys and having antinociceptive effects in traditional/alternative medicine. A wide range of phenolic substances resulting from edible plants have been reported to have noticeable antioxidant and anti-inflammatory actions, which enhance their chemopreventive potential. In this chapter we address the acute and chronic anti-inflammatory properties of gossypin in different in vivo models with inflammation induced by aspirin, carrageenan, formalin, dextran and croton oil. We will also discuss gossypin's antimelanoma properties based on a novel mechanism of action involving the RAF-MEK-ERK pathway. Finally, we will address the possibilities of using gossypin and its rationally designed analogues to develop proprietary drug candidates based on molecular docking studies.
| Original language | English (US) |
|---|---|
| Title of host publication | Chronic Inflammation |
| Subtitle of host publication | Causes, Treatment Options and Role in Disease |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 217-230 |
| Number of pages | 14 |
| ISBN (Print) | 9781628080940 |
| State | Published - 2013 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine