Natural killer and antibody-dependent cytotoxic activities in T cell chronic lymphocytic leukemia

S. Gupta, G. Fernandes

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

T cells from a patient with T cell chronic lymphocyte leukemia (CLL) were analysed for natural killer (NK) and antibody-dependent cytotoxicity (ADCC) and surface phenotype using a battery of monoclonal antibodies. T cells from the patient reacted with a pan T cell (9.6) and OKT8 (suppressor/cytotoxic phenotype) monoclonal antibodies and bore receptors for IgG Fc [T(g)] but lacked receptors for IgM Fc [T(m)] and did not react with OKT4 (helper/inducer phenotype) monoclonal antibody. T cells from the patient demonstrated a significantly higher (p < 0.01) NK activity when compared to control T cells. T cells from the patient also demonstrated strong but comparable ADCC when compared to healthy controls. The significance of these results is discussed.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalJournal of Clinical and Laboratory Immunology
Volume12
Issue number3
StatePublished - Dec 1 1983

ASJC Scopus subject areas

  • Immunology

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