Natural classes of treatment response

Andrew R. Morral, Martin Y. Iguchi, Mark A. Belding, Richard J. Lamb

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


This study examines an approach to identifying patterns of treatment response over time. Treatment response profiles are identified by cluster analyzing a repeated measure of patient performance collected at intervals during treatment. The procedure is demonstrated in Study 1 using monthly urinalysis results of 103 patients entering methadone maintenance treatment. The internal, external, and face validities of derived treatment response profiles are evaluated. A logistic regression model predicting treatment response is then constructed from intake variables found to correspond with the treatment response profiles. Study 2 replicates the procedures on an independent sample. Treatment response profiles facilitate the analysis of treatment response offering advantages over common measures of treatment outcome, such as performance at follow-up, change in performance from treatment entry to follow-up, or performance summed across treatment.

Original languageEnglish (US)
Pages (from-to)673-685
Number of pages13
JournalJournal of consulting and clinical psychology
Issue number4
StatePublished - Aug 1997
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology


Dive into the research topics of 'Natural classes of treatment response'. Together they form a unique fingerprint.

Cite this