Abstract
Background: Chagas disease is common in Central and South America and the southern United States. The causative agent is Trypanosoma cruzi (order Kinetoplastida, family Trypanosomatidae), a kinetoplastid protozoan parasite of humans and other vertebrates. It is a serious public health issue and the leading cause of heart disease and cardiovascular death in Central and South America. In 1984, a colony baboon was discovered to be infected with T. cruzi. Methods: As the initial diagnosis was made by microscopic observation of the amastigote forms of T. cruzi in myocardial fibers, T. cruzi amastigotes have been identified in three additional baboons. Results: The primary findings were similar in all four baboons and were congestive heart failure with edema of dependent areas, hydrothorax, hydropericardium, and multifocal to diffuse lymphoplasmacytic myocarditis. Conclusion: A baboon animal model of Chagas disease could contribute significantly to the development of therapies for the disease in humans.
Original language | English (US) |
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Pages (from-to) | 107-113 |
Number of pages | 7 |
Journal | Journal of medical primatology |
Volume | 38 |
Issue number | 2 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Animal model
- Heart
- Non-human primate
- Protozoa
- Trypanosoma cruzi
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)