Abstract
The potential antigonadotrophic properties of a number of synthetic and natural melatonin analogues were examined. Adult male hamsters received daily subcutaneous injections (25 μg/animal/day) each afternoon for 7 or 10 weeks. The only analogue to possess antigonadotrophic activity similar to melatonin was 6-chloromelatonin; melatonin and 6-chloromelatonin produced a significant reduction in both testicular and accessory sex organ weights, plasma LH and pituitary prolactin. These results suggest that, in the Syrian hamster, 6-chloromelatonin acts as a melatonin agonist and may be of use to elucidate further the physiological role of melatonin.
Original language | English (US) |
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Pages (from-to) | 187-197 |
Number of pages | 11 |
Journal | Journal of Neural Transmission |
Volume | 56 |
Issue number | 2-3 |
DOIs | |
State | Published - Jun 1983 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry