Natural and synthetic analogues of melatonin and related compounds II. Effects on plasma thyroid hormones and cholesterol levels in male Syrian hamsters

Mary K. Vaughan, B. A. Richardson, Linda Y Johnson, L. J. Petterborg, M. C. Powanda, Russel J Reiter, I. Smith

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Synthetic or natural analogues of the pineal indole, melatonin, were injected separately every evening (1700 hours) for 7 (Exp. 1) or 10 (Exp. 2) weeks into adult male Syrian hamsters maintained in 14 hours of light and 10 hours of darkness each day. Plasma thyroxine (T4) levels were significantly depressed by 25 μg/day of melatonin (aMT) in both experiments. Injecting 25 μg/day either of acetyl methoxytryptophol or of synthetic analogues (hexanoyl methoxytryptamine, propionyl methoxytryptophol, or 6-chloro-melatonin) in Exp. 1 or of a natural analogue (N-acetylserotonin, 6-hydroxymelatonin, hydroxytryptophol, or methoxytryptophol) in Exp. 2 had no effect on the circulating T4 levels. Plasma levels of triiodothyronine (T3) and thyrotropin (TSH) were unaffected in either experiment. Since none of the tested melatonin analogues is capable of suppressing circulating T4 concentration when given in a dose at which melatonin is reproducibly effective, the pineal-induced suppression of T4 is most likely mediated by melatonin. Plasma cholesterol levels were elevated only in hamsters receiving 6-chloromelatonin injections. However, plasma triglyceride levels were significantly higher than the diluent treated controls in Exp. 1 after injections of melatonin, acetyl methoxytryptophol, propionyl methoxytryptophol and 6-chloromelatonin. Interscapular brown adipose tissue was significantly heavier in melatonin treated animals.

Original languageEnglish (US)
Pages (from-to)279-291
Number of pages13
JournalJournal of Neural Transmission
Volume56
Issue number4
DOIs
StatePublished - Dec 1983

Fingerprint

Mesocricetus
Melatonin
Thyroid Hormones
Cholesterol
Hydroxytryptophol
5-Methoxytryptamine
Injections
Brown Adipose Tissue
Darkness
Triiodothyronine
Thyrotropin
Thyroxine
Cricetinae
Triglycerides
methoxytryptophol
Light

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Natural and synthetic analogues of melatonin and related compounds II. Effects on plasma thyroid hormones and cholesterol levels in male Syrian hamsters. / Vaughan, Mary K.; Richardson, B. A.; Johnson, Linda Y; Petterborg, L. J.; Powanda, M. C.; Reiter, Russel J; Smith, I.

In: Journal of Neural Transmission, Vol. 56, No. 4, 12.1983, p. 279-291.

Research output: Contribution to journalArticle

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