Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers

James L Morris, Yuan Fang, Keya De Mukhopdhyay, Michael J Wargovich

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Aerodigestive cancers are on an increasing level in both occurrence and mortality. A major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation and epigenetic silencing of normal regulatory genes. Here, we review the research on several natural products: silibinin, silymarin, quercetin, neem and nimbolide, gingerol, epigallatecatechin-3- gallate, curcumin, genistein, and resveratrol conducted on aerodigestive cancers. These types of cancers are primarily those from oral cavity, esophagus/windpipe, stomach, small and large intestine, colon/rectum, and bile/pancreas tissues. We report on the utilization in vivo and in vitro systems to research these dose effects on the inflammatory and epigenetic pathway components within the aerodigestive cancer. To follow up on the basic research, we will discuss the remaining research questions and future directions involving these natural products as putative stand alone or in combination with clinical agents.

Original languageEnglish (US)
Pages (from-to)11-20
Number of pages10
JournalCurrent Pharmacology Reports
Volume2
Issue number1
DOIs
StatePublished - Feb 1 2016

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Keywords

  • Aerodigestive cancer
  • EGCG
  • Genistein
  • Natural product
  • Quercetin
  • Resveratrol

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Biochemistry
  • Genetics

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