Natriuretic action of para aminohippurate (PAH)

M. D. Lifschitz

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Infusion of PAH during renal clearance experiments has been shown to increase urinary sodium excretion (U(Na)V). In addition, it has recently been suggested that accumulation of PAH and/or related compounds may be responsible for the increased U(Na)V per nephron in chronic renal failure. Therefore, studies were designed to determine whether the natriuretic effect of PAH was due to an osmotic effect, the action of a non reabsorbable anion, or, a direct effect on active sodium transport. NaPAH was infused into one renal artery of 12 anesthetized dogs which allowed renal arterial PAH concentration (RA(PAH)) to be raised with little systemic effect. There was no increase in U(Na)V with increasing rates of PAH administration until a RA(PAH) of 1.5 mM/L was achieved with an infusion rate of .07 mM/min. A higher rate of PAH administration (.19 mM/min) associated with a higher RA(PAH) led to an average increase in U(Na)V of 57 ± 11 uEq/min (mean ± SEM) (P<.01) compared with control periods. Mannitol given at this same rate (.19 mM/min) to the same dogs led to an increase in U(Na)V of 26 ± 10 uEq/min which was less (P<.01) than the increase in U(Na)V with PAH. Na2SO4 given at the same (.19 mEq/min) or a higher rate (.60 mEq/min) to the same dogs was associated with an increase in U(Na)V or 58 ± 18 and 211 ± 38 uEq/min, respectively. The urinary anions Cl, PAH and SO4 were measured in these studies and in the PAH and SO4 studies the increase in U(PAH)V or U(SO4)V was not different than the increase in U(Na)V (P>0.1). These results suggest that the natriuretic effect of PAH is mainly due to its effect as a non reabsorbable anion and offer no support for a direct effect on active sodium transport.

Original languageEnglish (US)
Pages (from-to)368A
JournalClinical Research
Issue number3
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)


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