National Institutes of Health Consensus Development Conference panel statement: Management of hepatitis C

D. W. Powell, B. Z. Abramson, J. A. Balint, S. Belle, J. R. Bloomer, A. K. Diehl, J. T. Frakes, G. Garcia-Tsao, E. W. Hook, J. M. Lusher, M. A. Popovsky, L. Rabeneck, A. L B Williams, T. S. Tralka, H. J. Alter, M. J. Alter, E. A. Bray, L. Curtis, J. Everhart, S. M. FeinstoneJ. H. Ferguson, J. S. Gress, W. H. Hall, J. H. Hoofnagle, L. D. Johnson, T. F. Kresina, K. L. Lindsay, A. Lok, P. R. McCurdy, R. P. Perrillo, R. H. Purcell, E. Schiff, W. D. Schwieterman, L. B. Seeff, C. R. Sherman, M. H. Stolar, A. Trachtenberg

Research output: Contribution to journalArticle

579 Citations (Scopus)

Abstract

The objective of this article is to provide health care providers, patients, and the general public with a responsible assessment of current available methods to diagnose, treat, and manage hepatitis C. A non-Federal, non-advocate, 12-member panel representing the fields of general internal medicine, hepatology, gastroenterology, infectious diseases, medical ethics, transfusion medicine, epidemiology, biostatistics, and the public participated. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1,600. The literature was searched through Medline, and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after conference. Hepatitis C is a common infection with variable course that can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The course of illness may be adversely affected by various factors, especially alcohol consumption. Therefore, more than one drink per day is strongly discouraged in patients with hepatitis C, and abstinence from alcohol is recommended. Initial therapy with interferon alfa (or equivalent) should be 3 million units three times per week for 12 months. Patients not responding to therapy after 3 months should not receive further treatment with interferon alone, but should be considered for combination therapy of interferon and ribavirin or for enrollment in investigational studies. Individuals infected with the hepatitis C virus (HCV) should not donate blood, organs, tissues, or semen. Safe sexual practices, including the use of latex condoms, is strongly encouraged for individuals with multiple sexual partners. Expansion of needle exchange programs should be considered in an effort to reduce the rate of transmission of hepatitis C among injection drug users.

Original languageEnglish (US)
JournalHepatology
Volume26
Issue number3 SUPPL.
StatePublished - 1997
Externally publishedYes

Fingerprint

Consensus Development Conferences
National Institutes of Health (U.S.)
Hepatitis C
Sexual Partners
Gastroenterology
Interferons
Needle-Exchange Programs
Biostatistics
Alcohol Abstinence
Transfusion Medicine
Literature
Medical Ethics
Ribavirin
Latex
Condoms
Bibliography
Chronic Hepatitis
Therapeutics
Internal Medicine
Drug Users

ASJC Scopus subject areas

  • Hepatology

Cite this

Powell, D. W., Abramson, B. Z., Balint, J. A., Belle, S., Bloomer, J. R., Diehl, A. K., ... Trachtenberg, A. (1997). National Institutes of Health Consensus Development Conference panel statement: Management of hepatitis C. Hepatology, 26(3 SUPPL.).

National Institutes of Health Consensus Development Conference panel statement : Management of hepatitis C. / Powell, D. W.; Abramson, B. Z.; Balint, J. A.; Belle, S.; Bloomer, J. R.; Diehl, A. K.; Frakes, J. T.; Garcia-Tsao, G.; Hook, E. W.; Lusher, J. M.; Popovsky, M. A.; Rabeneck, L.; Williams, A. L B; Tralka, T. S.; Alter, H. J.; Alter, M. J.; Bray, E. A.; Curtis, L.; Everhart, J.; Feinstone, S. M.; Ferguson, J. H.; Gress, J. S.; Hall, W. H.; Hoofnagle, J. H.; Johnson, L. D.; Kresina, T. F.; Lindsay, K. L.; Lok, A.; McCurdy, P. R.; Perrillo, R. P.; Purcell, R. H.; Schiff, E.; Schwieterman, W. D.; Seeff, L. B.; Sherman, C. R.; Stolar, M. H.; Trachtenberg, A.

In: Hepatology, Vol. 26, No. 3 SUPPL., 1997.

Research output: Contribution to journalArticle

Powell, DW, Abramson, BZ, Balint, JA, Belle, S, Bloomer, JR, Diehl, AK, Frakes, JT, Garcia-Tsao, G, Hook, EW, Lusher, JM, Popovsky, MA, Rabeneck, L, Williams, ALB, Tralka, TS, Alter, HJ, Alter, MJ, Bray, EA, Curtis, L, Everhart, J, Feinstone, SM, Ferguson, JH, Gress, JS, Hall, WH, Hoofnagle, JH, Johnson, LD, Kresina, TF, Lindsay, KL, Lok, A, McCurdy, PR, Perrillo, RP, Purcell, RH, Schiff, E, Schwieterman, WD, Seeff, LB, Sherman, CR, Stolar, MH & Trachtenberg, A 1997, 'National Institutes of Health Consensus Development Conference panel statement: Management of hepatitis C', Hepatology, vol. 26, no. 3 SUPPL..
Powell DW, Abramson BZ, Balint JA, Belle S, Bloomer JR, Diehl AK et al. National Institutes of Health Consensus Development Conference panel statement: Management of hepatitis C. Hepatology. 1997;26(3 SUPPL.).
Powell, D. W. ; Abramson, B. Z. ; Balint, J. A. ; Belle, S. ; Bloomer, J. R. ; Diehl, A. K. ; Frakes, J. T. ; Garcia-Tsao, G. ; Hook, E. W. ; Lusher, J. M. ; Popovsky, M. A. ; Rabeneck, L. ; Williams, A. L B ; Tralka, T. S. ; Alter, H. J. ; Alter, M. J. ; Bray, E. A. ; Curtis, L. ; Everhart, J. ; Feinstone, S. M. ; Ferguson, J. H. ; Gress, J. S. ; Hall, W. H. ; Hoofnagle, J. H. ; Johnson, L. D. ; Kresina, T. F. ; Lindsay, K. L. ; Lok, A. ; McCurdy, P. R. ; Perrillo, R. P. ; Purcell, R. H. ; Schiff, E. ; Schwieterman, W. D. ; Seeff, L. B. ; Sherman, C. R. ; Stolar, M. H. ; Trachtenberg, A. / National Institutes of Health Consensus Development Conference panel statement : Management of hepatitis C. In: Hepatology. 1997 ; Vol. 26, No. 3 SUPPL.
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abstract = "The objective of this article is to provide health care providers, patients, and the general public with a responsible assessment of current available methods to diagnose, treat, and manage hepatitis C. A non-Federal, non-advocate, 12-member panel representing the fields of general internal medicine, hepatology, gastroenterology, infectious diseases, medical ethics, transfusion medicine, epidemiology, biostatistics, and the public participated. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1,600. The literature was searched through Medline, and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after conference. Hepatitis C is a common infection with variable course that can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The course of illness may be adversely affected by various factors, especially alcohol consumption. Therefore, more than one drink per day is strongly discouraged in patients with hepatitis C, and abstinence from alcohol is recommended. Initial therapy with interferon alfa (or equivalent) should be 3 million units three times per week for 12 months. Patients not responding to therapy after 3 months should not receive further treatment with interferon alone, but should be considered for combination therapy of interferon and ribavirin or for enrollment in investigational studies. Individuals infected with the hepatitis C virus (HCV) should not donate blood, organs, tissues, or semen. Safe sexual practices, including the use of latex condoms, is strongly encouraged for individuals with multiple sexual partners. Expansion of needle exchange programs should be considered in an effort to reduce the rate of transmission of hepatitis C among injection drug users.",
author = "Powell, {D. W.} and Abramson, {B. Z.} and Balint, {J. A.} and S. Belle and Bloomer, {J. R.} and Diehl, {A. K.} and Frakes, {J. T.} and G. Garcia-Tsao and Hook, {E. W.} and Lusher, {J. M.} and Popovsky, {M. A.} and L. Rabeneck and Williams, {A. L B} and Tralka, {T. S.} and Alter, {H. J.} and Alter, {M. J.} and Bray, {E. A.} and L. Curtis and J. Everhart and Feinstone, {S. M.} and Ferguson, {J. H.} and Gress, {J. S.} and Hall, {W. H.} and Hoofnagle, {J. H.} and Johnson, {L. D.} and Kresina, {T. F.} and Lindsay, {K. L.} and A. Lok and McCurdy, {P. R.} and Perrillo, {R. P.} and Purcell, {R. H.} and E. Schiff and Schwieterman, {W. D.} and Seeff, {L. B.} and Sherman, {C. R.} and Stolar, {M. H.} and A. Trachtenberg",
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T1 - National Institutes of Health Consensus Development Conference panel statement

T2 - Management of hepatitis C

AU - Powell, D. W.

AU - Abramson, B. Z.

AU - Balint, J. A.

AU - Belle, S.

AU - Bloomer, J. R.

AU - Diehl, A. K.

AU - Frakes, J. T.

AU - Garcia-Tsao, G.

AU - Hook, E. W.

AU - Lusher, J. M.

AU - Popovsky, M. A.

AU - Rabeneck, L.

AU - Williams, A. L B

AU - Tralka, T. S.

AU - Alter, H. J.

AU - Alter, M. J.

AU - Bray, E. A.

AU - Curtis, L.

AU - Everhart, J.

AU - Feinstone, S. M.

AU - Ferguson, J. H.

AU - Gress, J. S.

AU - Hall, W. H.

AU - Hoofnagle, J. H.

AU - Johnson, L. D.

AU - Kresina, T. F.

AU - Lindsay, K. L.

AU - Lok, A.

AU - McCurdy, P. R.

AU - Perrillo, R. P.

AU - Purcell, R. H.

AU - Schiff, E.

AU - Schwieterman, W. D.

AU - Seeff, L. B.

AU - Sherman, C. R.

AU - Stolar, M. H.

AU - Trachtenberg, A.

PY - 1997

Y1 - 1997

N2 - The objective of this article is to provide health care providers, patients, and the general public with a responsible assessment of current available methods to diagnose, treat, and manage hepatitis C. A non-Federal, non-advocate, 12-member panel representing the fields of general internal medicine, hepatology, gastroenterology, infectious diseases, medical ethics, transfusion medicine, epidemiology, biostatistics, and the public participated. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1,600. The literature was searched through Medline, and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after conference. Hepatitis C is a common infection with variable course that can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The course of illness may be adversely affected by various factors, especially alcohol consumption. Therefore, more than one drink per day is strongly discouraged in patients with hepatitis C, and abstinence from alcohol is recommended. Initial therapy with interferon alfa (or equivalent) should be 3 million units three times per week for 12 months. Patients not responding to therapy after 3 months should not receive further treatment with interferon alone, but should be considered for combination therapy of interferon and ribavirin or for enrollment in investigational studies. Individuals infected with the hepatitis C virus (HCV) should not donate blood, organs, tissues, or semen. Safe sexual practices, including the use of latex condoms, is strongly encouraged for individuals with multiple sexual partners. Expansion of needle exchange programs should be considered in an effort to reduce the rate of transmission of hepatitis C among injection drug users.

AB - The objective of this article is to provide health care providers, patients, and the general public with a responsible assessment of current available methods to diagnose, treat, and manage hepatitis C. A non-Federal, non-advocate, 12-member panel representing the fields of general internal medicine, hepatology, gastroenterology, infectious diseases, medical ethics, transfusion medicine, epidemiology, biostatistics, and the public participated. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1,600. The literature was searched through Medline, and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after conference. Hepatitis C is a common infection with variable course that can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The course of illness may be adversely affected by various factors, especially alcohol consumption. Therefore, more than one drink per day is strongly discouraged in patients with hepatitis C, and abstinence from alcohol is recommended. Initial therapy with interferon alfa (or equivalent) should be 3 million units three times per week for 12 months. Patients not responding to therapy after 3 months should not receive further treatment with interferon alone, but should be considered for combination therapy of interferon and ribavirin or for enrollment in investigational studies. Individuals infected with the hepatitis C virus (HCV) should not donate blood, organs, tissues, or semen. Safe sexual practices, including the use of latex condoms, is strongly encouraged for individuals with multiple sexual partners. Expansion of needle exchange programs should be considered in an effort to reduce the rate of transmission of hepatitis C among injection drug users.

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