National Institute of Allergy and Infectious Diseases workshop report: “Chlamydia vaccines: The way forward”

Guangming Zhong, Robert C. Brunham, Luis M. de la Maza, Toni Darville, Carolyn Deal

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Chlamydia trachomatis (Ct), an intracellular pathogen, is the most common bacterial sexually transmitted infection. In addition to acute cervicitis and urethritis, Ct can lead to serious sequelae of significant public health burden including pelvic inflammatory disease (PID) and infertility. Ct control efforts have not resulted in desired outcomes such as reduced incidence and reinfection, and this highlights the need for the development of an effective Ct vaccine. To this end, NIAID organized a workshop to consider the current status of Ct vaccine research and address critical questions in Ct vaccine design and clinical testing. Topics included the goal(s) of a vaccine and the feasibility of achieving these goals, animal models of infection including mouse and nonhuman primate (NHP) models, and correlates of protection to guide vaccine design. Decades of research have provided both whole cell-based and subunit vaccine candidates for development. At least one is currently in clinical development and efforts now need to be directed toward further development of the most attractive candidates. Overall, the discussions and presentations from the workshop highlighted optimism about the current status of Ct vaccine research and detailed the remaining gaps and questions needed to move vaccines forward.

Original languageEnglish (US)
Pages (from-to)7346-7354
Number of pages9
JournalVaccine
Volume37
Issue number50
DOIs
StatePublished - Nov 28 2019

Keywords

  • Chlamydia trachomatis
  • Chlamydia vaccine
  • Vaccine development

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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