Abstract
A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocaine exposure, D3-agonist-elicited yawning was enhanced, and quinpirole led to persistent operant responding only if conditioned stimuli associated with cocaine were presented for responding. Finally, a more selective D3 partial agonist was reported that had a novel profile of activity that could have relevance to the suppression of dopamine-related compulsions.
Original language | English (US) |
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Pages (from-to) | 498-502 |
Number of pages | 5 |
Journal | Experimental and Clinical Psychopharmacology |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2008 |
Keywords
- dopamine D2 receptor
- dopamine D3 receptor
- impulse control disorders
- pramipexole
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)
- Pharmacology