Narrowing in on Compulsions: Dopamine Receptor Functions

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocaine exposure, D3-agonist-elicited yawning was enhanced, and quinpirole led to persistent operant responding only if conditioned stimuli associated with cocaine were presented for responding. Finally, a more selective D3 partial agonist was reported that had a novel profile of activity that could have relevance to the suppression of dopamine-related compulsions.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalExperimental and Clinical Psychopharmacology
Volume16
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • dopamine D2 receptor
  • dopamine D3 receptor
  • impulse control disorders
  • pramipexole

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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