Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

Saira F. Bakshi, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei V Tumanov, Craig D. Woodworth, Sergiy Minko, Dmitry M. Kolpashchikov, Evgeny Katz

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

Original languageEnglish (US)
Pages (from-to)1356-1365
Number of pages10
JournalNanoscale
Volume10
Issue number3
DOIs
StatePublished - Jan 21 2018

ASJC Scopus subject areas

  • Materials Science(all)

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    Bakshi, S. F., Guz, N., Zakharchenko, A., Deng, H., Tumanov, A. V., Woodworth, C. D., Minko, S., Kolpashchikov, D. M., & Katz, E. (2018). Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. Nanoscale, 10(3), 1356-1365. https://doi.org/10.1039/c7nr08581h