Abstract
A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.
Original language | English (US) |
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Pages (from-to) | 1356-1365 |
Number of pages | 10 |
Journal | Nanoscale |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Jan 21 2018 |
ASJC Scopus subject areas
- General Materials Science