Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

Saira F. Bakshi, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei V Tumanov, Craig D. Woodworth, Sergiy Minko, Dmitry M. Kolpashchikov, Evgeny Katz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

Original languageEnglish (US)
Pages (from-to)1356-1365
Number of pages10
JournalNanoscale
Volume10
Issue number3
DOIs
StatePublished - Jan 21 2018

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Nanoreactors
Catalytic DNA
Biomimetics
Biomarkers
Brushes
Magnetic fields
Nanoparticles
Messenger RNA
Copolymers
Imaging techniques
Kinetics
Sensors

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Bakshi, S. F., Guz, N., Zakharchenko, A., Deng, H., Tumanov, A. V., Woodworth, C. D., ... Katz, E. (2018). Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. Nanoscale, 10(3), 1356-1365. https://doi.org/10.1039/c7nr08581h

Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. / Bakshi, Saira F.; Guz, Nataliia; Zakharchenko, Andrey; Deng, Han; Tumanov, Alexei V; Woodworth, Craig D.; Minko, Sergiy; Kolpashchikov, Dmitry M.; Katz, Evgeny.

In: Nanoscale, Vol. 10, No. 3, 21.01.2018, p. 1356-1365.

Research output: Contribution to journalArticle

Bakshi, SF, Guz, N, Zakharchenko, A, Deng, H, Tumanov, AV, Woodworth, CD, Minko, S, Kolpashchikov, DM & Katz, E 2018, 'Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field', Nanoscale, vol. 10, no. 3, pp. 1356-1365. https://doi.org/10.1039/c7nr08581h
Bakshi, Saira F. ; Guz, Nataliia ; Zakharchenko, Andrey ; Deng, Han ; Tumanov, Alexei V ; Woodworth, Craig D. ; Minko, Sergiy ; Kolpashchikov, Dmitry M. ; Katz, Evgeny. / Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field. In: Nanoscale. 2018 ; Vol. 10, No. 3. pp. 1356-1365.
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