Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field

Saira F. Bakshi, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei V. Tumanov, Craig D. Woodworth, Sergiy Minko, Dmitry M. Kolpashchikov, Evgeny Katz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.

Original languageEnglish (US)
Pages (from-to)1356-1365
Number of pages10
JournalNanoscale
Volume10
Issue number3
DOIs
StatePublished - Jan 21 2018

ASJC Scopus subject areas

  • Materials Science(all)

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