Nanofunctionalized Stent-Mediated Local Heat Treatment for the Suppression of Stent-Induced Tissue Hyperplasia

Jung Hoon Park, Wooram Park, Soojeong Cho, Kun Yung Kim, Jiaywei Tsauo, Sung Hwan Yoon, Woo Chan Son, Dong Hyun Kim, Ho Young Song

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Current therapeutic strategies are insufficient for suppressing stent-induced restenosis. Here, branched gold nanoparticles (BGNP)-coated self-expandable metallic stents (SEMSs) were developed for a local heat-induced suppression of stent-related tissue hyperplasia. Our polydopamine (PDA) coating on SEMS allowed BGNP crystal growth on the surface of SEMSs. The prepared BGNP-coated SEMS showed effective local heating under near-infrared laser irradiation. The effectiveness of BGNP-coated SEMSs for suppressing stent-related tissue hyperplasia was demonstrated in a rat esophageal model (n = 52). BGNP-coated SEMS placement under fluoroscopic guidance was technically successful in all rats. The placed BGNP-coated SEMS in rat esophagus achieved three different local heat dose ranges (50, 65, and 80 °C) under fluoroscopic image-guided local irradiation. Follow-up endoscopic examination readily monitored the local heating and observed significantly decreased tissue hyperplasia at 4 weeks of local heat treatments (50 and 65 °C). Finally, Western blot, histology, immunohistochemistry (HSP70, αSMA, and TUNEL), and immunofluorescence (Ki67 and BrdU) analyses along with the statistical analysis confirmed that optimized BGNP-coated SEMS-mediated local heat treatments inducing the expression of anti-inflammatory HSP70 effectively suppresses tissue hyperplasia after stent placement in the esophagus. Our local heating with nanofunctionalized stents represents a promising new approach for suppressing stent-related tissue hyperplasia.

Original languageEnglish (US)
Pages (from-to)29357-29366
Number of pages10
JournalACS Applied Materials and Interfaces
Volume10
Issue number35
DOIs
StatePublished - Sep 5 2018

Keywords

  • gold nanoparticles
  • local heat therapy
  • nanofunctionalization
  • self-expandable metallic stent
  • tissue hyperplasia

ASJC Scopus subject areas

  • Materials Science(all)

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