Naltrexone decreases D-amphetamine and ethanol self-administration in rhesus monkeys

Corina Jimenez-Gomez, Gail Winger, Reginald L. Dean, Daniel R. Deaver, James H. Woods

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Amphetamines are the second most highly abused illicit drugs worldwide, yet there is no pharmacological treatment for amphetamine abuse and dependence. Preclinical studies and, more recently, human studies, suggest that the opioid receptor antagonist, naltrexone, might be useful in the treatment of amphetamine abuse. Naltrexone, an opioid receptor antagonist, is currently used for the treatment of alcohol dependence. The aim of this study was to explore the ability of naltrexone to modify selfadministration of amphetamine or ethanol in rhesus monkeys. Monkeys were trained to respond to intravenous injections of either D-amphetamine (0.003 mg/kg/injection) or ethanol (0.05 g/kg/injection) on a fixed ratio 30 schedule. Naltrexone (0.01-1 mg/kg) was administered intramuscularly 30 min before the start of treatment test sessions. Naltrexone dose-dependently decreased both amphetamine and ethanol self-administration. These findings support the potential use of naltrexone as therapy for amphetamine and polydrug abuse.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalBehavioural pharmacology
Volume22
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • Amphetamine
  • Ethanol
  • Naltrexone
  • Opioid receptor antagonist
  • Rhesus monkey
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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