Naked Mole Rat

Rochelle Buffenstein, Thomas Park, Martha Hanes, James E. Artwohl

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

Naked mole rats are mouse-sized rodents that have become an important animal model in biomedical research. They play a unique mammalian role in behavioral and ecophysiological research of life underground. This chapter studies the general physiology, anatomy of organ systems, husbandry, and uses in research of the naked mole rats. Naked mole rats belong to the order Rodentia in that they have two incisor teeth on the upper and lower arcade that continuously grow. The skin is loose, wrinkled, and brownish pink in color. The body is for the most part absent of hairs with the exception of tactile hairs that are regularly arranged throughout the body and which are particularly prominent around the face and to a lesser extent on the tail. They are typically housed at 28-30°C, and at 50-60% relative humidity. Because naked mole rats are social and have cooperative behaviors, the study of their conduct has more applicability to people. The chapter describes the models of experimental research on the naked mole rat such as the model of reproductive suppression, model of somatosensory processing, model of bone elongation, and model of aging.

Original languageEnglish (US)
Title of host publicationThe Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
PublisherElsevier Inc.
Pages1055-1074
Number of pages20
ISBN (Print)9780123809209
DOIs
StatePublished - Dec 1 2012

Keywords

  • Anatomy
  • Batherygidae
  • Diseases
  • Health
  • Heterocephalus glaber
  • Naked mole rat
  • Physiology
  • Reproduction
  • Uses in research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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