N-terminal pro-B-type natriuretic peptide in early and advanced phases of obesity

Harald Mangge, Gunter Almer, Sieglinde Zelzer, Ramachandran Vasan, Elisabeth Kraigher-Krainer, Robert Gasser, Wolfgang Schnedl, Rottraut Ille, Sandra Wallner, Reinhard Möller, Renate Horejsi, Daniel Weghuber

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Increased plasma amino-terminal-cleavage-fragment of NP (NT-proBNP) is an established indicator for heart failure. Moreover, obese adults had low circulating NT-proBNP suggesting an obesity-related dysregulation (natriuretic handicap). Secretion and/or clearance of NT-proBNP were discussed to be impaired in obesity. As only older adults were investigated so far, it remains unclear when during the evolution of obesity the state of a natriuretic handicap develops, and whether NT-proBNP may still serve as a relevant cardiac marker in obese juveniles. Methods: We analysed NT-proBNP in juvenile (n=274, 10-18 years) and middle-aged (n=277, 18-50 years) normal weight (n=213) and obese (n=338) probands together with complex anthropometry, carotis sonography, clinical, and laboratory parameters. Results: NT-proBNP showed a significant gender and age interaction. Adult females had significant higher NT-proBNP than adult males, and higher levels than juvenile females. Adult males had lower levels than juvenile males. Only a weak age and weight interaction was seen with obese juveniles which showed higher NT-proBNP than obese adults. Moreover, normal weight probands had higher NT-proBNP than overweight and obese. In a multiple regression including all probands, gender, creatinine and uric acid were the best predictors for NT-proBNP. In adults, female gender is the strongest driver for increased NT-proBNP. Conclusions: These results argue against an essential influence of obesity to B-type cardiac natriuretic hormone system regulation in the absence of heart failure, and suggest NT-proBNP as a useful cardiac marker irrespective of age and obesity.

Original languageEnglish (US)
Pages (from-to)1539-1545
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume49
Issue number9
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Keywords

  • Natriuretic deficit
  • NT-proBNP
  • Obese adults
  • Obese juveniles

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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