Abstract
The position of the indole in the indolomorphinans, which includes the δ opioid antagonist naltrindole, is considered to be responsible for the δ opioid selectivity for this class of ligands. Herein is described the N-cyclohexylethyl substituted N-nor-derivative, which is shown to be μ preferring. Thus, the nature of the N-substituent is equally important to the receptor selectivity for this class of ligands. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 2449-2451 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 10 |
Issue number | 21 |
DOIs | |
State | Published - Nov 6 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry