N-cyclohexylethyl-N-noroxymorphindole: A μ-opioid preferring analogue of naltrindole

Andrew Coop, Arthur E. Jacobson, Mario D. Aceto, Louis S. Harris, John R. Traynor, James H. Woods, Kenner C. Rice

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The position of the indole in the indolomorphinans, which includes the δ opioid antagonist naltrindole, is considered to be responsible for the δ opioid selectivity for this class of ligands. Herein is described the N-cyclohexylethyl substituted N-nor-derivative, which is shown to be μ preferring. Thus, the nature of the N-substituent is equally important to the receptor selectivity for this class of ligands. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2449-2451
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number21
DOIs
StatePublished - Nov 6 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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