Mzf1 controls cell proliferation and tumorigenesis

M. Gaboli, P. A. Kotsi, C. Gurrieri, G. Cattoretti, S. Ronchetti, C. Cordon-Cardo, H. E. Broxmeyer, R. Hromas, P. P. Pandolfi

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

MZF1 is a transcription factor belonging to the Krüppel family of zinc finger proteins, expressed in totipotent hemopoietic cells as well as in myeloid progenitors. Here we have inactivated Mzfi1 by gene targeting. Mzf1-/- mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic population of cells of myeloid origin reminiscent of human chloromas. Mzf1 inactivation results in a striking increase of the autonomous cell proliferation and of the ability of Mzf1-/- hemopoietic progenitors to sustain long-term hemopoiesis. These findings demonstrate that Mzf1 can act as a tumor/ growth suppressor in the hemopoietic compartment.

Original languageEnglish (US)
Pages (from-to)1625-1630
Number of pages6
JournalGenes and Development
Volume15
Issue number13
DOIs
StatePublished - Jul 1 2001
Externally publishedYes

Keywords

  • Hematopoiesis
  • Knockout mice
  • MZF
  • Myeloid progenitors
  • Tumorigenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Gaboli, M., Kotsi, P. A., Gurrieri, C., Cattoretti, G., Ronchetti, S., Cordon-Cardo, C., Broxmeyer, H. E., Hromas, R., & Pandolfi, P. P. (2001). Mzf1 controls cell proliferation and tumorigenesis. Genes and Development, 15(13), 1625-1630. https://doi.org/10.1101/gad.902301