TY - JOUR
T1 - Myxomatous neoplasms in the perineal region of baboons
AU - Wallace, Shannon M.
AU - Szabo, Kathleen A.
AU - Schlabritz-Loutsevitch, Natalia E.
AU - Dick, Edward J.
AU - Blanchard, Terrell W.
AU - Hubbard, Gene B.
PY - 2008
Y1 - 2008
N2 - Background: In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years. Methods: We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants. Results: Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features. Conclusion: Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.
AB - Background: In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years. Methods: We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants. Results: Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features. Conclusion: Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms.
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U2 - 10.1111/j.1600-0684.2008.00293.x
DO - 10.1111/j.1600-0684.2008.00293.x
M3 - Article
C2 - 19017193
AN - SCOPUS:55449093588
SN - 0047-2565
VL - 37
SP - 261
EP - 270
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
IS - 6
ER -