Myofibrillar myopathy: No evidence of apoptosis by TUNEL

Anthony A. Amato, Carlayne E. Jackson, Shellye Lampkin, Kathleen Kagan-Hallet

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The pathogenesis of myofibrillar myopathy (MFM) is not known. Muscle biopsy specimens demonstrate increased expression of cell cycle regulatory proteins as well as the ectopic expression of lamin B and nuclear matrix protein in the cytoplasm, suggesting the possibility of apoptosis. The authors investigated for apoptosis using the TUNEL method in six muscle biopsy specimens from patients with MFM. There was no evidence of apoptotic myonuclei in any of the MFM muscle biopsies. Further studies regarding the pathogenesis of MFM and the possible role of mitotic catastrophe are needed.

Original languageEnglish (US)
Pages (from-to)861-863
Number of pages3
JournalNeurology
Volume52
Issue number4
DOIs
StatePublished - Mar 10 1999

ASJC Scopus subject areas

  • Clinical Neurology

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