TY - JOUR
T1 - Myofibrillar myopathy
T2 - No evidence of apoptosis by TUNEL
AU - Amato, Anthony A.
AU - Jackson, Carlayne E.
AU - Lampkin, Shellye
AU - Kagan-Hallet, Kathleen
PY - 1999/3/10
Y1 - 1999/3/10
N2 - The pathogenesis of myofibrillar myopathy (MFM) is not known. Muscle biopsy specimens demonstrate increased expression of cell cycle regulatory proteins as well as the ectopic expression of lamin B and nuclear matrix protein in the cytoplasm, suggesting the possibility of apoptosis. The authors investigated for apoptosis using the TUNEL method in six muscle biopsy specimens from patients with MFM. There was no evidence of apoptotic myonuclei in any of the MFM muscle biopsies. Further studies regarding the pathogenesis of MFM and the possible role of mitotic catastrophe are needed.
AB - The pathogenesis of myofibrillar myopathy (MFM) is not known. Muscle biopsy specimens demonstrate increased expression of cell cycle regulatory proteins as well as the ectopic expression of lamin B and nuclear matrix protein in the cytoplasm, suggesting the possibility of apoptosis. The authors investigated for apoptosis using the TUNEL method in six muscle biopsy specimens from patients with MFM. There was no evidence of apoptotic myonuclei in any of the MFM muscle biopsies. Further studies regarding the pathogenesis of MFM and the possible role of mitotic catastrophe are needed.
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U2 - 10.1212/wnl.52.4.861
DO - 10.1212/wnl.52.4.861
M3 - Article
C2 - 10078743
AN - SCOPUS:0033541084
SN - 0028-3878
VL - 52
SP - 861
EP - 863
JO - Neurology
JF - Neurology
IS - 4
ER -