MyoD1 protein expression in alveolar soft part sarcoma as confirmatory evidence of its skeletal muscle nature

J. Rosai, P. Dias, D. M. Parham, D. N. Shapiro, P. Houghton

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.

Original languageEnglish (US)
Pages (from-to)974-981
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume15
Issue number10
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Keywords

  • Alveolar soft part sarcoma
  • MyoD1
  • MyoD1 protein
  • Skeletal muscle
  • Soft tissue tumors

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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