TY - JOUR
T1 - Myocardial Ischemia
AU - Hillis, L. David
AU - Braunwald, Eugene
PY - 1977/5/12
Y1 - 1977/5/12
N2 - Pharmacologic Interventions A number of pharmacologic agents reduce myocardial ischemic injury in the laboratory animal, and some have been used in limited numbers of patients. The activation of the complement system via its alternate pathway, a shift that characterizes ischemic tissue, releases leukotactic factors and increases capillary permeability, leading to interstitial edema. As a result, the microvasculature is compressed, further diminishing blood flow to the ischemic area.18,233,234 Cobra-venom factor, a protein that enzymatically cleaves C3 and prevents the effects of the complement system, reduces myocardial injury.196,197 Similarly, the kallikrein system enhances leukotactic activity, capillary permeability, interstitial edema and proteolytic activity.
AB - Pharmacologic Interventions A number of pharmacologic agents reduce myocardial ischemic injury in the laboratory animal, and some have been used in limited numbers of patients. The activation of the complement system via its alternate pathway, a shift that characterizes ischemic tissue, releases leukotactic factors and increases capillary permeability, leading to interstitial edema. As a result, the microvasculature is compressed, further diminishing blood flow to the ischemic area.18,233,234 Cobra-venom factor, a protein that enzymatically cleaves C3 and prevents the effects of the complement system, reduces myocardial injury.196,197 Similarly, the kallikrein system enhances leukotactic activity, capillary permeability, interstitial edema and proteolytic activity.
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U2 - 10.1056/NEJM197705122961905
DO - 10.1056/NEJM197705122961905
M3 - Review article
C2 - 403473
AN - SCOPUS:0017346379
VL - 296
SP - 1093
EP - 1096
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 19
ER -