Abstract
The myeloproliferative neoplasms are a group of clonal hematological (stem cell) disorders with terminal myeloid cell expansion in the peripheral blood. Originally described by William Dameshek in 1951 based on clinical and bone marrow similarities, in 2001 myeloproliferative neoplasms were classified by the World Health Organization Classification which was updated in 2008. Myeloproliferative neoplasms are classified into five major entities (acute myeloid and lymphoid leukemias are separate entities). Myeloproliferative neoplasms can be divided into "classic" forms, which are chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis, and "atypical" forms, consisting of chronic neutrophilic leukemia, chronic eosinophilic leukemia not otherwise specified, mastocytosis and myeloproliferative neoplasm unclassifiable. The four "classic" myeloproliferative neoplasms will be discussed in this chapter, given their rarity.
| Original language | English (US) |
|---|---|
| Title of host publication | Textbook of Uncommon Cancer |
| Publisher | John Wiley and Sons |
| Pages | 647-658 |
| Number of pages | 12 |
| ISBN (Print) | 9781118083734 |
| DOIs | |
| State | Published - Sep 20 2012 |
| Externally published | Yes |
Keywords
- CEL
- CML
- CNL
- Essential thrombocythemia
- MPNs
- Polycythemia vera
- Primary myelofibrosis
- SM
ASJC Scopus subject areas
- Medicine(all)