Myeloproliferative disorders and the hyperviscosity syndrome

Bruce D Adams, Russell Baker, J. Abraham Lopez, Susan Spencer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.

Original languageEnglish (US)
Pages (from-to)585-602
Number of pages18
JournalHematology/Oncology Clinics of North America
Volume24
Issue number3
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Myeloproliferative Disorders
Plasma Exchange
Emergency Medicine
Disease Susceptibility
Neurologic Manifestations
Referral and Consultation
Hemorrhage
Serum
Proteins

Keywords

  • Essential thrombocytosis
  • Hyperleukocytosis
  • Hyperviscosity syndrome
  • Leukostasis
  • Polycythemia vera
  • Waldenstrom macroglobulinemia

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Myeloproliferative disorders and the hyperviscosity syndrome. / Adams, Bruce D; Baker, Russell; Lopez, J. Abraham; Spencer, Susan.

In: Hematology/Oncology Clinics of North America, Vol. 24, No. 3, 06.2010, p. 585-602.

Research output: Contribution to journalArticle

Adams, Bruce D ; Baker, Russell ; Lopez, J. Abraham ; Spencer, Susan. / Myeloproliferative disorders and the hyperviscosity syndrome. In: Hematology/Oncology Clinics of North America. 2010 ; Vol. 24, No. 3. pp. 585-602.
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