Myeloproliferative disorders and the hyperviscosity syndrome

Bruce D. Adams; Russell Baker; J. Abraham Lopez; Susan Spencer

doi:10.1016/j.hoc.2010.03.004

Myeloproliferative disorders and the hyperviscosity syndrome

Bruce D. Adams, Russell Baker, J. Abraham Lopez, Susan Spencer

Emergency Medicine

Research output: Contribution to journal › Review article

17 Scopus citations

Abstract

Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.

Original language	English (US)
Pages (from-to)	585-602
Number of pages	18
Journal	Hematology/Oncology Clinics of North America
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.hoc.2010.03.004
State	Published - Jun 1 2010

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Keywords

Essential thrombocytosis
Hyperleukocytosis
Hyperviscosity syndrome
Leukostasis
Polycythemia vera
Waldenstrom macroglobulinemia

ASJC Scopus subject areas

Hematology
Oncology

Cite this

Adams, B. D., Baker, R., Lopez, J. A., & Spencer, S. (2010). Myeloproliferative disorders and the hyperviscosity syndrome. Hematology/Oncology Clinics of North America, 24(3), 585-602. https://doi.org/10.1016/j.hoc.2010.03.004

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10.1016/j.hoc.2010.03.004