Abstract
Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 585-602 |
| Number of pages | 18 |
| Journal | Hematology/Oncology Clinics of North America |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2010 |
| Externally published | Yes |
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Keywords
- Essential thrombocytosis
- Hyperleukocytosis
- Hyperviscosity syndrome
- Leukostasis
- Polycythemia vera
- Waldenstrom macroglobulinemia
ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Myeloproliferative disorders and the hyperviscosity syndrome. / Adams, Bruce D; Baker, Russell; Lopez, J. Abraham; Spencer, Susan.
In: Hematology/Oncology Clinics of North America, Vol. 24, No. 3, 06.2010, p. 585-602.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myeloproliferative disorders and the hyperviscosity syndrome
AU - Adams, Bruce D
AU - Baker, Russell
AU - Lopez, J. Abraham
AU - Spencer, Susan
PY - 2010/6
Y1 - 2010/6
N2 - Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.
AB - Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.
KW - Essential thrombocytosis
KW - Hyperleukocytosis
KW - Hyperviscosity syndrome
KW - Leukostasis
KW - Polycythemia vera
KW - Waldenstrom macroglobulinemia
UR - http://www.scopus.com/inward/record.url?scp=77952949493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952949493&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2010.03.004
DO - 10.1016/j.hoc.2010.03.004
M3 - Article
C2 - 20488356
AN - SCOPUS:77952949493
VL - 24
SP - 585
EP - 602
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
SN - 0889-8588
IS - 3
ER -