Myeloproliferative disorders and the hyperviscosity syndrome

Bruce D. Adams, Russell Baker, J. Abraham Lopez, Susan Spencer

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Myeloproliferative disorders and the serum hyperviscosity syndrome can rapidly manifest with emergent presentations. Hyperviscosity occurs from pathologic elevations of either the cellular or acellular (protein) fractions of the circulating blood. Classic hyperviscosity syndrome presents with the triad of bleeding diathesis, visual disturbances, and focal neurologic signs. Emergency medicine providers should be aware of these conditions and be prepared to rapidly initiate supportive and early definitive management, including plasma exchange and apharesis. Early consultation with a hematologist is essential to managing these complex patients.

Original languageEnglish (US)
Pages (from-to)585-602
Number of pages18
JournalHematology/Oncology Clinics of North America
Issue number3
StatePublished - Jun 2010
Externally publishedYes


  • Essential thrombocytosis
  • Hyperleukocytosis
  • Hyperviscosity syndrome
  • Leukostasis
  • Polycythemia vera
  • Waldenstrom macroglobulinemia

ASJC Scopus subject areas

  • Hematology
  • Oncology


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