Mycosis fungoides with follicular mucinosis displaying aggressive tumor-stage transformation: Successful treatment using radiation therapy plus oral bexarotene combination therapy

Narin Apisarnthanarax, Chul S. Ha, Madeleine Duvic

Research output: Contribution to journalArticle

14 Scopus citations


Follicular mucinosis is a tissue reaction pattern characterized by mucin deposition with follicular sebaceous units and is found as an idiopathic, primary, benign process (alopecia mucinosa), or as a secondary process due to inflammatory and neoplastic disorders (mycosis fungoides). When associated with follicular mucinosis, mycosis fungoides commonly pursues an aggressive course, often undergoing large-cell transformation, which is associated with resistance to therapy and poor prognosis. We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. In this setting, the patient was treated with local radiation therapy, total-skin electron beam therapy, and therapy and maintenance with the oral retinoid-X-receptor retinoid bexarotene, and achieved a durable complete remission.

Original languageEnglish (US)
Pages (from-to)429-433
Number of pages5
JournalAmerican Journal of Clinical Dermatology
Issue number6
StatePublished - Jun 27 2003


ASJC Scopus subject areas

  • Dermatology

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