Myc and Max homologs in Drosophila

Peter Gallant, Yuzuru Shiio, Pei Feng Cheng, Susan M. Parkhurst, Robert N. Eisenman

Research output: Contribution to journalArticlepeer-review

155 Scopus citations


The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.

Original languageEnglish (US)
Pages (from-to)1523-1527
Number of pages5
Issue number5292
StatePublished - Nov 29 1996
Externally publishedYes

ASJC Scopus subject areas

  • General


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