Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma

C. Eng, K. A. Foster, C. S. Healey, C. Houghton, S. A. Gayther, L. M. Mulligan, B. A.J. Ponder

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.

Original languageEnglish (US)
Pages (from-to)339-341
Number of pages3
JournalBritish Journal of Cancer
Volume74
Issue number3
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Endothelin-B receptor
  • MEN 2
  • Medullary thyroid carcinoma
  • Phaeochromocytoma
  • RET
  • c-mos

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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