Abstract
The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.
Original language | English (US) |
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Pages (from-to) | 339-341 |
Number of pages | 3 |
Journal | British Journal of Cancer |
Volume | 74 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
Keywords
- Endothelin-B receptor
- MEN 2
- Medullary thyroid carcinoma
- Phaeochromocytoma
- RET
- c-mos
ASJC Scopus subject areas
- Oncology
- Cancer Research