Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

Paul Hasty, Allan Bradley, Julia H. Morris, Diane G. Edmondson, Judith M. Venuti, Eric N. Olson, William H. Klein

Research output: Contribution to journalArticle

933 Scopus citations

Abstract

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalNature
Volume364
Issue number6437
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene'. Together they form a unique fingerprint.

Cite this