Muscle-bone crosstalk and potential therapies for sarco-osteoporosis

Guo Bin Li, Lan Zhang, Dong En Wang, Luban AIQudsy, Jean X. Jiang, Hui Yun Xu, Peng Shang

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


The nature of muscle-bone crosstalk has been historically considered to be only mechanical, where the muscle is the load applier while bone provides the attachment sites. However, this dogma has been challenged with the emerging notion that bone and muscle act as secretory endocrine organs affect the function of each other. Biochemical crosstalk occurs through myokines such as myostatin, irisin, interleukin (IL)-6, IL-7, IL-15, insulin-like growth factor-1, fibroblast growth factor (FGF)-2, and β-aminoisobutyric acid and through bone-derived factors including FGF23, prostaglandin E2, transforming growth factor β, osteocalcin, and sclerostin. Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone-muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.

Original languageEnglish (US)
Pages (from-to)14262-14273
Number of pages12
JournalJournal of Cellular Biochemistry
Issue number9
StatePublished - Sep 2019


  • bone
  • crosstalk
  • muscle
  • myokines
  • osteoporosis
  • sarcopenia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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