Murine circadian susceptibility rhythm to cyclophosphamide

E. Haus, G. Fernandes, J. F.W. Kuhl, E. J. Yunis, J. K. Lee, F. Halberg

Research output: Contribution to journalArticle

30 Scopus citations


Mice of several strains received a single injection of cyclophosphamide at one of 6 different circadian system stages, 4 hr apart, under conditions of 24 hr light dark synchronized rhythmometry. Despite differences in genetic background of the populations investigated over a span of 8 yr in several separate studies, the overall pool of information on hand reveals a statistically significant rhythm in susceptibility to this widely used chemotherapeutic agent.

Original languageEnglish (US)
Pages (from-to)270-277
Number of pages8
Issue number3
StatePublished - Dec 1 1974


ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Haus, E., Fernandes, G., Kuhl, J. F. W., Yunis, E. J., Lee, J. K., & Halberg, F. (1974). Murine circadian susceptibility rhythm to cyclophosphamide. Chronobiologia, 1(3), 270-277.