Murine circadian susceptibility rhythm to cyclophosphamide

E. Haus, G. Fernandes, J. F.W. Kuhl, E. J. Yunis, J. K. Lee, F. Halberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Mice of several strains received a single injection of cyclophosphamide at one of 6 different circadian system stages, 4 hr apart, under conditions of 24 hr light dark synchronized rhythmometry. Despite differences in genetic background of the populations investigated over a span of 8 yr in several separate studies, the overall pool of information on hand reveals a statistically significant rhythm in susceptibility to this widely used chemotherapeutic agent.

Original languageEnglish (US)
Pages (from-to)270-277
Number of pages8
Issue number3
StatePublished - Dec 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology


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