Mice of several strains received a single injection of cyclophosphamide at one of 6 different circadian system stages, 4 hr apart, under conditions of 24 hr light dark synchronized rhythmometry. Despite differences in genetic background of the populations investigated over a span of 8 yr in several separate studies, the overall pool of information on hand reveals a statistically significant rhythm in susceptibility to this widely used chemotherapeutic agent.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Dec 1 1974|
ASJC Scopus subject areas
- Developmental Biology