Abstract
Mupirocin resistance was determined in consecutive oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus clinical isolates collected over 14 months at a university hospital during 1991 and 1992. Twenty of 86 (23%) oxacillin-resistant and borderline oxacillin-resistant S. aureus isolates were mupirocin resistant; 80% were high-level resistant. Prior mupirocin use was a significant risk factor (relative risk, 6.08; 95% confidence interval, 3.7 to 9.99). Seven of 20 resistant isolates were distinct strains, as determined by pulsed-field gel electrophoresis typing. Two instances of clonal dissemination of a single strain occurred, but several other distinct mupirocin-resistant strains were documented. Mupirocin resistance was unexpectedly common among these isolates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1664-1667 |
| Number of pages | 4 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 38 |
| Issue number | 7 |
| DOIs |
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| State | Published - 1994 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology