Abstract
Computer simulation is a commonly used tool both in genetic epidemiology and in anthropological genetics. We describe here various methods for simulating multivariate quantitative genetic evolution and apply these methods in an analysis of craniometrics from two Pacific island samples. The results of this application indicate that the two samples (one from the Tolai and one from the Moriori) are significantly different, even when allowing for founder effect, intense selection on founders, and genetic drift. The simulation methods we describe and use are commonly applied in animal breeding studies and are much more efficient and general than the multilocus gene-dropping technique usually used in anthropological genetics simulations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 897-915 |
| Number of pages | 19 |
| Journal | Human Biology |
| Volume | 65 |
| Issue number | 6 |
| State | Published - Dec 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Genetics(clinical)
Cite this
Multivariate quantitative genetic simulations in anthropology with an example from the South Pacific. / Konigsberg, L. W.; Blangero, J.
In: Human Biology, Vol. 65, No. 6, 12.1993, p. 897-915.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multivariate quantitative genetic simulations in anthropology with an example from the South Pacific.
AU - Konigsberg, L. W.
AU - Blangero, J.
PY - 1993/12
Y1 - 1993/12
N2 - Computer simulation is a commonly used tool both in genetic epidemiology and in anthropological genetics. We describe here various methods for simulating multivariate quantitative genetic evolution and apply these methods in an analysis of craniometrics from two Pacific island samples. The results of this application indicate that the two samples (one from the Tolai and one from the Moriori) are significantly different, even when allowing for founder effect, intense selection on founders, and genetic drift. The simulation methods we describe and use are commonly applied in animal breeding studies and are much more efficient and general than the multilocus gene-dropping technique usually used in anthropological genetics simulations.
AB - Computer simulation is a commonly used tool both in genetic epidemiology and in anthropological genetics. We describe here various methods for simulating multivariate quantitative genetic evolution and apply these methods in an analysis of craniometrics from two Pacific island samples. The results of this application indicate that the two samples (one from the Tolai and one from the Moriori) are significantly different, even when allowing for founder effect, intense selection on founders, and genetic drift. The simulation methods we describe and use are commonly applied in animal breeding studies and are much more efficient and general than the multilocus gene-dropping technique usually used in anthropological genetics simulations.
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M3 - Article
VL - 65
SP - 897
EP - 915
JO - Human Biology
JF - Human Biology
SN - 0018-7143
IS - 6
ER -