Multivariate quantitative genetic simulations in anthropology with an example from the South Pacific.

L. W. Konigsberg, J. Blangero

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Computer simulation is a commonly used tool both in genetic epidemiology and in anthropological genetics. We describe here various methods for simulating multivariate quantitative genetic evolution and apply these methods in an analysis of craniometrics from two Pacific island samples. The results of this application indicate that the two samples (one from the Tolai and one from the Moriori) are significantly different, even when allowing for founder effect, intense selection on founders, and genetic drift. The simulation methods we describe and use are commonly applied in animal breeding studies and are much more efficient and general than the multilocus gene-dropping technique usually used in anthropological genetics simulations.

Original languageEnglish (US)
Pages (from-to)897-915
Number of pages19
JournalHuman Biology
Volume65
Issue number6
StatePublished - Dec 1993
Externally publishedYes

Fingerprint

anthropology
Anthropology
quantitative genetics
Pacific Islands
Founder Effect
simulation
Genetic Drift
Molecular Epidemiology
Molecular Evolution
founder effect
Computer Simulation
Breeding
animal breeding
genetic drift
Pacific Ocean Islands
epidemiology
methodology
computer simulation
breeding
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Multivariate quantitative genetic simulations in anthropology with an example from the South Pacific. / Konigsberg, L. W.; Blangero, J.

In: Human Biology, Vol. 65, No. 6, 12.1993, p. 897-915.

Research output: Contribution to journalArticle

Konigsberg, L. W. ; Blangero, J. / Multivariate quantitative genetic simulations in anthropology with an example from the South Pacific. In: Human Biology. 1993 ; Vol. 65, No. 6. pp. 897-915.
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